{"id":6583,"date":"2021-05-30T23:08:07","date_gmt":"2021-05-30T15:08:07","guid":{"rendered":"http:\/\/lifeclinic.com.hk\/the-functional-approach-to-infertility-2\/"},"modified":"2025-04-14T11:16:35","modified_gmt":"2025-04-14T03:16:35","slug":"turning-back-clock-with-nad","status":"publish","type":"post","link":"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/","title":{"rendered":"Turning Back The Clock With NAD+"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"vc_row wpb_row vc_row-fluid\">\n<div class=\"wpb_column vc_column_container vc_col-sm-6\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 counter-hierarchy ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title ez-toc-toggle\" style=\"cursor:pointer\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#What_Is_NAD\" >What Is NAD+<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#The_Functions_of_NAD\" >The Functions of NAD+:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#NAD_Levels_Decline_with_Age\" >NAD+ Levels Decline with Age<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#Why_is_NAD_Important_to_Combat_Aging\" >Why is NAD+ Important to Combat Aging?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#Benefits_of_NAD_Therapy_For_Aging\" >Benefits of NAD+ Therapy For Aging<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#1_Contribute_to_longer_telomeres\" >1. Contribute to longer telomeres<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#2_Promotes_DNA_Repair\" >2. Promotes DNA Repair<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#3_Induces_Energy-Intensive_Enzymes\" >3. Induces Energy-Intensive Enzymes<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#4_Promotes_Chromosome_Stability\" >4. Promotes Chromosome Stability<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#5_NAD_is_a_Neurotransmitter\" >5. NAD is a Neurotransmitter<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#6_Activates_Sirtuins\" >6. Activates Sirtuins<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#7_Supports_Energy_Production\" >7. Supports Energy Production<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#Safety_of_NAD_Therapy\" >Safety of NAD+ Therapy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/lifeclinic.com.hk\/turning-back-clock-with-nad\/#References\" >References<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_Is_NAD\"><\/span><span style=\"font-size: 18pt;\">What Is NAD+<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes and is an essential component of energy production (mitochondrial function).<\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_Functions_of_NAD\"><\/span><span style=\"font-size: 18pt;\">The Functions of NAD+:<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>DNA repair<\/li>\n<li>Cell repair<\/li>\n<li>Turning genes on and off<\/li>\n<li>Maintaining neurotransmitter levels<\/li>\n<li>Communicating with cells<\/li>\n<li>Producing ATP in cells<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"vc_row wpb_row vc_row-fluid\">\n<div class=\"wpb_column vc_column_container vc_col-sm-12\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<h2><span class=\"ez-toc-section\" id=\"NAD_Levels_Decline_with_Age\"><\/span><span style=\"font-size: 18pt;\">NAD+ Levels Decline with Age<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Scientists know that NAD+ is one of the most important molecules in the body and that we lose it with age, resulting in a variety of health issues. Unfortunately NAD+ levels steadily decline during aging and by middle age, NAD+ has fallen to half of youthful levels and down to 1%-10% at the age of 80.\u00a0 The decline of NAD+ results in the change in sirtuins and PARP activity which impacts our brain function in particular as that is where most NAD+ receptors are located.\u00a0 The decline in NAD+ causes memory issues, mood issues and also anxiety in many patients.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div  class=\"wpb_single_image wpb_content_element vc_align_left wpb_content_element\">\n\t\t\n\t\t<figure class=\"wpb_wrapper vc_figure\">\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"618\" height=\"396\" src=\"https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/nad-declines-with-age-eng-1.png\" class=\"vc_single_image-img attachment-full\" alt=\"Nad+ decline\" title=\"Nad+\" srcset=\"https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/nad-declines-with-age-eng-1.png 618w, https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/nad-declines-with-age-eng-1-300x192.png 300w, https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/nad-declines-with-age-eng-1-16x10.png 16w\" sizes=\"auto, (max-width: 618px) 100vw, 618px\" \/><\/div>\n\t\t<\/figure>\n\t<\/div>\n<div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"vc_row wpb_row vc_row-fluid\">\n<div class=\"wpb_column vc_column_container vc_col-sm-12\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<h2><span class=\"ez-toc-section\" id=\"Why_is_NAD_Important_to_Combat_Aging\"><\/span><span style=\"font-size: 18pt;\">Why is NAD+ Important to Combat Aging?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Dr. David Sinclair and his colleagues at Harvard discovered recently that NAD+ levels decline as we age which also has an effect on other processes that rely on NAD+.\u00a0 A class of genes, known as sirtuins, play a large role in how the body ages by regulating inflammation and DNA protection. Sirtuins depend on NAD+ to start and stop protective pathways that are linked to age-related diseases.\u00a0 In other words, sirtuins are able to \u201cturn on\u201d and \u201cturn off\u201d certain genes like a light switch.<\/p>\n<p>Inflammation causes damage to our DNA and other structures in our cells, which can lead to cell death.\u00a0 When we eat inflammatory foods, breathe in pollutants or are exposed to other toxic chemicals, our cells are at risk.\u00a0 With bountiful amounts of NAD+, your cells are able to activate genes to prevent and correct DNA damage.\u00a0 Superhero genes, such as sirtuins, allow your cells to live long and healthy lives, leading to a better quality of life for you.<\/p>\n<\/div>\n<\/div>\n<div class=\"vc_empty_space\"><\/div>\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<h2><span class=\"ez-toc-section\" id=\"Benefits_of_NAD_Therapy_For_Aging\"><\/span><span style=\"font-size: 18pt;\">Benefits of NAD+ Therapy For Aging<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Administering a high dose of NAD+, through NAD+ therapy, can optimise your NAD+ levels, which revs up the cell\u2019s engines (called the mitochondrion) translating into more energy and a range of potential benefits.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"1_Contribute_to_longer_telomeres\"><\/span><span style=\"font-size: 14pt;\"><strong>1. Contribute to longer telomeres<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>The possibility of extending telomere length with NAD+ holds out hope for slowing the aging process and improving longevity.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"2_Promotes_DNA_Repair\"><\/span><span style=\"font-size: 14pt;\"><strong>2. Promotes DNA Repair<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Improving DNA repair with NAD+ may slow cellular aging, reduce the persistence of cancer-causing mutations, and play an important role in preventing inflammatory conditions such as atherosclerosis.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"3_Induces_Energy-Intensive_Enzymes\"><\/span><span style=\"font-size: 14pt;\"><strong>3. Induces Energy-Intensive Enzymes<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Improving the energy-extraction process in all cells with NAD+ increases their capacity to do the work they are specialized for. It also protects mitochondria from early death, a benefit that is associated with reduced cellular aging and lowered risks for cardiovascular and brain disease.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"4_Promotes_Chromosome_Stability\"><\/span><span style=\"font-size: 14pt;\"><strong>4. Promotes Chromosome Stability<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>NAD+ supplementation is a promising cutting edge strategy to improve chromosome stability, a treatment that may slow down cellular aging (senescence) and lower the risk of cancer.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"5_NAD_is_a_Neurotransmitter\"><\/span><span style=\"font-size: 14pt;\"><strong>5. NAD is a Neurotransmitter<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Ample NAD+ nutrition is essential for sustaining brain health, cognitive function, and preventing neurodegenerative decline.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"6_Activates_Sirtuins\"><\/span><span style=\"font-size: 14pt;\"><strong>6. Activates Sirtuins<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Sirtuin activation has shown great promise in fighting cardiovascular disease and preserving aging brain function, but these longevity-promoters cannot function without sufficient NAD+.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"7_Supports_Energy_Production\"><\/span><span style=\"font-size: 14pt;\"><strong>7. Supports Energy Production<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Supporting efficient energy production and adequate ATP levels requires consistent and abundant NAD+. This is critical because waning energy supplies contribute to the aging process.<\/p>\n<h4><\/h4>\n<h2><span class=\"ez-toc-section\" id=\"Safety_of_NAD_Therapy\"><\/span><span style=\"font-size: 18pt;\">Safety of NAD+ Therapy<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Numerous clinical trials have been published on NAD+ Therapy and it is typically very well-tolerated[4]. Side effects are typically mild, such as flushing, and would be monitored by the medical professional administering the therapy.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h2><span class=\"ez-toc-section\" id=\"References\"><\/span><span style=\"font-size: 12pt;\"><strong>References<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>1. Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes<\/em><br \/>\n<em>2. Blander G, Guarente L (2004). \u201cThe Sir2 family of protein deacetylases\u201d; Annu. Rev. Biochem. 73: 417\u201335.<\/em><br \/>\n<em>3. B\u00fcrkle A (2005). \u201cPoly(ADP-ribose). The most elaborate metabolite of NAD+.\u201d FEBS J. 272(18): 4576\u201389.<\/em><br \/>\n<em>4. Dietrich C, Charles B, Claire LK. \u201cSafety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults.\u201d Sci Rep. 2019 Jul 5;9(1):9772. doi: 10.1038\/s41598-019-46120-z.<\/em><\/p>\n\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"What Is NAD+ Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes and is an essential component of energy production (mitochondrial function). The Functions of NAD+: DNA repair Cell repair Turning genes on and off Maintaining neurotransmitter levels Communicating with cells Producing ATP in cells [...]","protected":false},"author":4,"featured_media":6586,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[252,202],"tags":[],"class_list":["post-6583","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anti-aging","category-biohacking"],"acf":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/nad.jpeg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/posts\/6583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/comments?post=6583"}],"version-history":[{"count":3,"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/posts\/6583\/revisions"}],"predecessor-version":[{"id":8875,"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/posts\/6583\/revisions\/8875"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/media\/6586"}],"wp:attachment":[{"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/media?parent=6583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/categories?post=6583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/wp-json\/wp\/v2\/tags?post=6583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}