{"id":6588,"date":"2021-05-30T23:13:45","date_gmt":"2021-05-30T15:13:45","guid":{"rendered":"http:\/\/lifeclinic.com.hk\/turning-back-the-clock-with-nad\/"},"modified":"2025-04-14T11:13:09","modified_gmt":"2025-04-14T03:13:09","slug":"chelation-for-heavy-metal-detox","status":"publish","type":"post","link":"https:\/\/lifeclinic.com.hk\/zh\/chelation-for-heavy-metal-detox\/","title":{"rendered":"Chelation For Heavy Metal Detoxification"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>Toxins enter our bodies via several channels including through our food, our drinking water, the pollution in the air we breathe in, and even through our skin transdermally.<\/p>\n<p>These toxins are carried into our liver whereby they undergo detoxification reactions so that can be removed from our body. However, if our body system is unable to remove them, they are carried by the bloodstream all over our body and can accumulate for years. Chelation is a medical detoxification treatment to pull heavy metals from our tissues and excrete them safely.<\/p>\n\n\t\t<\/div>\n\t<\/div>\n<div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div  class=\"wpb_single_image wpb_content_element vc_align_left wpb_content_element\">\n\t\t\n\t\t<figure class=\"wpb_wrapper vc_figure\">\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/air-pollution-fossil-fuels-kris-kru\u0308g-flickr.jpeg\" class=\"vc_single_image-img attachment-full\" alt=\"Heavy Metals\" title=\"Heavy Metals\" srcset=\"https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/air-pollution-fossil-fuels-kris-kru\u0308g-flickr.jpeg 1024w, https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/air-pollution-fossil-fuels-kris-kru\u0308g-flickr-300x225.jpeg 300w, https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/air-pollution-fossil-fuels-kris-kru\u0308g-flickr-768x576.jpeg 768w, https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/05\/air-pollution-fossil-fuels-kris-kru\u0308g-flickr-16x12.jpeg 16w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div>\n\t\t<\/figure>\n\t<\/div>\n<div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"vc_row wpb_row vc_row-fluid\">\n<div class=\"wpb_column vc_column_container vc_col-sm-12\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"vc_separator wpb_content_element vc_separator_align_center vc_sep_width_100 vc_sep_pos_align_center vc_sep_color_grey vc_separator-has-text\">\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 counter-hierarchy ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title ez-toc-toggle\" style=\"cursor:pointer\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/lifeclinic.com.hk\/zh\/chelation-for-heavy-metal-detox\/#What_Is_Chelation\" >What Is Chelation?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/lifeclinic.com.hk\/zh\/chelation-for-heavy-metal-detox\/#Chelating_Agents\" >Chelating Agents<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/lifeclinic.com.hk\/zh\/chelation-for-heavy-metal-detox\/#1_EDTA_ethylenediaminmnetetraacetic_acid\" >1. EDTA (ethylenediaminmnetetraacetic acid)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/lifeclinic.com.hk\/zh\/chelation-for-heavy-metal-detox\/#2_DMPS_23-Dimercapto-1-propanesulfonic_acid\" >2. DMPS (2,3-Dimercapto-1-propanesulfonic acid)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/lifeclinic.com.hk\/zh\/chelation-for-heavy-metal-detox\/#Summary_Points\" >Summary Points<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/lifeclinic.com.hk\/zh\/chelation-for-heavy-metal-detox\/#Safety_Of_Chelation\" >Safety Of Chelation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/lifeclinic.com.hk\/zh\/chelation-for-heavy-metal-detox\/#References\" >\u53c3\u8003\u8cc7\u6599<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_Is_Chelation\"><\/span><span style=\"font-size: 18pt;\"><strong>What Is Chelation?<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/div>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p>Chelation comes from the Greek word \u201cChee\u201d which means claw. Chelation therapy is a process whereby a chemical compound is injected intravenously into the bloodstream to draw out the heavy metals from the body. But in the process, other minerals may also be drawn out of the body too. When these substances are injected into the body, they grab hold of the metals and minerals such as lead, mercury, copper, iron, arsenic, aluminum and calcium and excrete them out of the money through the bowels or the kidneys.<\/p>\n<p>Depending on the metal toxic burden in the body, oral or intravenous applied DMPS or DMSA or EDTA may be used for follow-up treatments. The treatment regime can be weekly or monthly treatments given over a period of time. A repeat provocation test is usually recommended after 10 chelation treatments or in a 3 month period if the treatments are done weekly. The follow-up provocation test is used to evaluate the patient response and success of treatment.<\/p>\n<p>In certain patients who are symptomatic but with unbelievably low levels of heavy metals after the challenge, it may be worthwhile to stimulate bile drainage with Solidago, Vitamin C, Selenium, and Zinc for about a month and repeat the test which typically reports a higher value. This is likely that the patient is a bile excretory and eliminates mercury predominantly via stool. Giving sulfurous, bile-accessible substances such as wild garlic or coriander would loosen the heavy metals from deep places and mobilize it better for elimination.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"vc_empty_space\"><\/div>\n<div class=\"vc_separator wpb_content_element vc_separator_align_center vc_sep_width_100 vc_sep_pos_align_center vc_sep_color_grey vc_separator-has-text\">\n<h2><span class=\"ez-toc-section\" id=\"Chelating_Agents\"><\/span><span style=\"font-size: 18pt;\"><strong>Chelating Agents<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/div>\n<div class=\"vc_empty_space\"><\/div>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p><em>As chelation uses an external chemical to draw out heavy metals, there are different chelating agents. The main agents are EDTA and DMPS with specific pros and cons.\u00a0\u00a0<\/em><\/p>\n<h3><span class=\"ez-toc-section\" id=\"1_EDTA_ethylenediaminmnetetraacetic_acid\"><\/span><span style=\"font-size: 14pt;\"><strong>1. EDTA (ethylenediaminmnetetraacetic acid)<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>EDTA is a chelator that is very effective in treating heavy metals, especially lead and cadmium toxicity. It is an FDA approved method for the treatment of lead poisoning. Some physicians have used IV EDTA to treat coronary artery disease and atherosclerosis, although this form of treatment is still controversial. Proponents of this method believe that EDTA which usually binds with the calcium in the bones, also acts to bind calcium deposits from plaques in the arteries and this helps to \u201cclean out\u201d the calcium plaques from the arteries and reduce risk of heart disease.<\/p>\n<p>There is a recent study to show the effectiveness of EDTA therapy for preventing cardiovascular events especially in diabetic patients with a history of heart attack. The Trial to Assess Chelation Therapy (TACT), found an amazing 40% reduction in total mortality, 40% reduction in recurrent heart attacks and about 50% reduction in overall mortality in patients with diabetes who previously suffered from a heart attack.\u00a0 TACT was a large, randomised, placebo-controlled study published in JAMA that randomised patients to a series of IV chelation using EDTA or placebo. (1)\u00a0Some patients also report reduced pain from chronic inflammatory diseases like arthritis, as it acts as an antioxidant to remove inflammatory processes in the body.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"2_DMPS_23-Dimercapto-1-propanesulfonic_acid\"><\/span><span style=\"font-size: 14pt;\"><strong>2. DMPS (2,3-Dimercapto-1-propanesulfonic acid)<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Another intravenous agent used for mercury detoxification is called DMPS (2,3-Dimercapto-1-propanesulfonic acid). It belongs to the thiol group which binds metals to sulfhydryl groups. It has been registered in Germany since 1997 and is available as a prescription item in various countries. DMPS is routinely used as an antidote for heavy metal poisoning and for the treatment of chronic metal overexposure. DMPS is considered the most effective for the binding and elimination of arsenic and mercury, but also useful for lead. DMPS provocation tests are used by physicians before initiating treatment to diagnose the severity of the heavy metal burden in the body. DMPS effectively binds antimony, arsenic and mercury.<\/p>\n<\/div>\n<p>DMPS is useful to be used in a provocation test to evaluate chronic metal exposures. This allows the physician to identify the type of metal accumulating in the body and helps to select the most appropriate chelating agent for the treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Summary_Points\"><\/span><span style=\"font-size: 18pt;\"><strong>Summary Points<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>EDTA with its strong calcium binding ability, is the preferred option for the treatment of calcium deposits in coronary vessels in cardiovascular disease. It is also preferred if lead and cadmium are high.<\/li>\n<li>DMPS is most suitable\u00a0 for multiple metal exposure, especially when overexposure to antimony, arsenic and mercury are suspected. The intravenous treatment binds metals more effectively than the oral application.<\/li>\n<li>Oral DMSA is not a strong chelating agent but has good lead binding ability. The advantage is that it does not bind effectively to essential elements like calcium, copper and zinc. Hence, it is suitable for children and the elderly. (2)<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"vc_empty_space\"><\/div>\n<div class=\"vc_separator wpb_content_element vc_separator_align_center vc_sep_width_100 vc_sep_pos_align_center vc_sep_color_grey vc_separator-has-text\">\n<h2><span class=\"ez-toc-section\" id=\"Safety_Of_Chelation\"><\/span><span style=\"font-size: 18pt;\"><strong>Safety Of Chelation<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/div>\n<div class=\"vc_empty_space\"><\/div>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p>Chelation is considered a safe medical procedure however it may not be applicable for all individuals. Some of the negative side effects of EDTA therapy include kidney damage at high doses, or high blood pressure, headache, and rashes. It is important to monitor the renal function during the IV EDTA chelation treatment.<\/p>\n<p>Chelating agents have a strong affinity for metals, including the nutrient metals. For DMPS, it has a strong copper binding ability, EDTA binds strongly to zinc and calcium. If the patient\u2019s nutritional status is not evaluated, the prolonged use of chelating agents can lead to certain mineral deficiencies. Hence during chelation treatment, physicians should monitor closely the patient\u2019s nutritional status and supplement or replace deficient nutrients as necessary before starting or during the chelation treatment\u00a0to keep them from losing these minerals in the process of chelation.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"vc_empty_space\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"vc_row wpb_row vc_row-fluid\">\n<div class=\"wpb_column vc_column_container vc_col-sm-12\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"vc_separator wpb_content_element vc_separator_align_center vc_sep_width_100 vc_sep_pos_align_center vc_sep_color_grey vc_separator-has-text\">\n<h2><span class=\"ez-toc-section\" id=\"References\"><\/span><span style=\"font-size: 12pt;\">\u53c3\u8003\u8cc7\u6599<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/div>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<ol>\n<li>\n<p class=\"get-citation-citation\"><em>Sears ME. Chelation: harnessing and enhancing heavy metal detoxification\u2013a review.\u00a0ScientificWorldJournal. 2013;2013:219840. Published 2013 Apr 18. doi:10.1155\/2013\/219840<\/em><\/p>\n<\/li>\n<li>\n<p class=\"get-citation-citation\"><em>This Week in JAMA.\u00a0JAMA.\u00a02013;309(12):1201. doi:10.1001\/jama.2012.145324<\/em><\/p>\n<\/li>\n<li><em>Comparison of Chelating Agents DMPS, DMSA, and EDTA for the diagnosis and treatment of chronic metal exposure. British Journal of Medicine and Medical Research 4(9):1821-1835, 2014<\/em><\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h4><strong>\u53c3\u8003\u8cc7\u6599<\/strong><\/h4>\n<p><em>1. Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes<\/em><br \/>\n<em>2. Blander G, Guarente L (2004). \u201cThe Sir2 family of protein deacetylases\u201d; Annu. Rev. Biochem. 73: 417\u201335.<\/em><br \/>\n<em>3. B\u00fcrkle A (2005). \u201cPoly(ADP-ribose). The most elaborate metabolite of NAD+.\u201d FEBS J. 272(18): 4576\u201389.<\/em><br \/>\n<em>4. Dietrich C, Charles B, Claire LK. \u201cSafety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults.\u201d Sci Rep. 2019 Jul 5;9(1):9772. doi: 10.1038\/s41598-019-46120-z.<\/em><\/p>\n\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"Toxins enter our bodies via several channels including through our food, our drinking water, the pollution in the air we breathe in, and even through our skin transdermally. These toxins are carried into our liver whereby they undergo detoxification reactions so that can be removed from our body. However, if our body system is unable [...]","protected":false},"author":4,"featured_media":6456,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[202],"tags":[],"class_list":["post-6588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biohacking"],"acf":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2020\/07\/18_01_can_air_pollution-1.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/posts\/6588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/comments?post=6588"}],"version-history":[{"count":3,"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/posts\/6588\/revisions"}],"predecessor-version":[{"id":8874,"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/posts\/6588\/revisions\/8874"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/media\/6456"}],"wp:attachment":[{"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/media?parent=6588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/categories?post=6588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh\/wp-json\/wp\/v2\/tags?post=6588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}