{"id":6593,"date":"2021-06-01T11:47:25","date_gmt":"2021-06-01T03:47:25","guid":{"rendered":"http:\/\/lifeclinic.com.hk\/chelation-for-heavy-metal-detoxification\/"},"modified":"2025-04-14T11:05:18","modified_gmt":"2025-04-14T03:05:18","slug":"cytokine-therapy-for-anti-aging","status":"publish","type":"post","link":"https:\/\/lifeclinic.com.hk\/zh_cn\/cytokine-therapy-for-anti-aging\/","title":{"rendered":"Cytokine Therapy for Anti-Aging"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>Cytokines, from the Greek cyto meaning \u201ccell\u201d and kinos meaning \u201cmovement\u201d, are tiny protein molecules secreted by cells that communicate with other cells. Cytokines may be classified as peptides, proteins, exosomes, secretomes or glycoproteins.<\/p>\n<p>Sophisticated and profound complexes of cytokines found in our bodies are involved in cellular communications. They are nano-sized molecules working as cross-cell messengers and channels.<\/p>\n<p>It might help to think of cytokines as the body\u2019s mobile phone system.<\/p>\n\n\t\t<\/div>\n\t<\/div>\n<div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div  class=\"wpb_single_image wpb_content_element vc_align_left wpb_content_element\">\n\t\t\n\t\t<figure class=\"wpb_wrapper vc_figure\">\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"814\" height=\"588\" src=\"https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/06\/Cytokines-Graphic-August-2017.jpeg\" class=\"vc_single_image-img attachment-full\" alt=\"\" title=\"Cytokines-Graphic-August-2017\" srcset=\"https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/06\/Cytokines-Graphic-August-2017.jpeg 814w, https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/06\/Cytokines-Graphic-August-2017-300x217.jpeg 300w, https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/06\/Cytokines-Graphic-August-2017-768x555.jpeg 768w, https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/06\/Cytokines-Graphic-August-2017-16x12.jpeg 16w\" sizes=\"auto, (max-width: 814px) 100vw, 814px\" \/><\/div>\n\t\t<\/figure>\n\t<\/div>\n<div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div>\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 counter-hierarchy ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title ez-toc-toggle\" style=\"cursor:pointer\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/lifeclinic.com.hk\/zh_cn\/cytokine-therapy-for-anti-aging\/#The_Functions_Of_Cytokines_In_Aging\" >The Functions Of Cytokines In Aging<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/lifeclinic.com.hk\/zh_cn\/cytokine-therapy-for-anti-aging\/#Cytokine_Therapy_For_Anti-Aging\" >Cytokine Therapy For Anti-Aging<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/lifeclinic.com.hk\/zh_cn\/cytokine-therapy-for-anti-aging\/#Reduced_inflammation\" >Reduced inflammation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/lifeclinic.com.hk\/zh_cn\/cytokine-therapy-for-anti-aging\/#Improved_skin_appearance\" >Improved skin appearance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/lifeclinic.com.hk\/zh_cn\/cytokine-therapy-for-anti-aging\/#Improved_immune_system_regulation\" >Improved immune system regulation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/lifeclinic.com.hk\/zh_cn\/cytokine-therapy-for-anti-aging\/#Prevent_cognitive_decline\" >Prevent cognitive decline<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/lifeclinic.com.hk\/zh_cn\/cytokine-therapy-for-anti-aging\/#Pain_reduction\" >Pain reduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/lifeclinic.com.hk\/zh_cn\/cytokine-therapy-for-anti-aging\/#Improved_weight_management\" >Improved weight management<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"The_Functions_Of_Cytokines_In_Aging\"><\/span><span style=\"font-size: 18pt;\">The Functions Of Cytokines In Aging<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>A crucial component of how well we age is related to the levels of inflammation in the body. Although inflammation is a natural and healthy response, prolonged elevated levels become disastrous for the body, linked to chronic diseases, and accelerated aging. This interconnected link has given rise to a new term, \u2018inflamm-aging\u2019. Although research is still elucidating the exact causes of \u201cinflamm-aging\u201d, a common finding involves the dysregulation of the cytokine network.<\/p>\n<p>Cytokines communicate with both near and far cells in the following three ways:<\/p>\n<ul>\n<li><strong>Autocrine action:<\/strong> affecting only the cell from which it was secreted<\/li>\n<li><strong>Paracrine action<\/strong>: affecting only neighbouring cells<\/li>\n<li><strong>Endocrine action:<\/strong> allowing hormones to affect cells in a distant area through the blood circulation<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Cytokine_Therapy_For_Anti-Aging\"><\/span><span style=\"font-size: 18pt;\">Cytokine Therapy For Anti-Aging<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Cytokines can be the difference between the body\u2019s success and failure. An imbalance of cytokines is at the root of most diseases as the cells are either lacking the correct signals to keep healthy, or are receiving the wrong signals.<\/p>\n<p>Cytokine therapy involves administering external cytokines to the body. It is one of the new exciting fields in medicine which, like stem cells, could dramatically change the face of medicine and treatment protocols to support a variety of conditions.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Reduced_inflammation\"><\/span><span style=\"font-size: 18pt;\">Reduced inflammation<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Inflammation is at the root of all chronic diseases. As messenger molecules, cytokines can either be pro-inflammatory (IL-1, TNF-\u03b1) or anti-inflammatory (IL-4, IL-6). Blocking pro-inflammatory cytokine levels with their antagonists is an effective and highly selective method for reducing inflammation.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Improved_skin_appearance\"><\/span><span style=\"font-size: 18pt;\">Improved skin appearance<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Cytokines play a key role in the aging process of the skin, including loss of collagen, increase in skin infections, compromised wound-healing, and dry, wrinkled texture. With cytokine therapy, these signaling pathways can be targeted to improve the function, integrity, and appearance of our skin.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Improved_immune_system_regulation\"><\/span><span style=\"font-size: 18pt;\">Improved immune system regulation<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>When the body encounters an acute infection, cytokines are secreted from our immune cells and rush to the site to signal for help. This reaction is called a \u2018cytokine storm\u2019 and creates a localized site of inflammation and immune activity to deal with the invader. As such, cytokines are vital players in our immune regulation and can be harnessed for their potential therapeutic effects for cancer and autoimmune diseases like inflammatory bowel disease, psoriasis, and rheumatoid arthritis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Prevent_cognitive_decline\"><\/span><span style=\"font-size: 18pt;\">Prevent cognitive decline<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Research has shown that the levels of individual cytokines can affect learning, memory, and synaptic plasticity. One of the targeted pathways is through modulating brain inflammation, which has disastrous effects on brain function and neurodegeneration. We also see a casual link between cytokine deregulation and the progression of neurological diseases like Alzheimer\u2019s disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Pain_reduction\"><\/span><span style=\"font-size: 18pt;\">Pain reduction<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>As we age, aches and pains become a common complaint. Cytokines are largely to blame for daily pains, whether from joints, bones, or muscles. Research has shown that cytokine crosstalk between immune, glial, and neural cells is integral to the development of pain symptoms and targeting these pathways to manipulate cytokine interactions can be a successful strategy to manage inflammation and pain.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Improved_weight_management\"><\/span><span style=\"font-size: 18pt;\">Improved weight management<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Cytokines have been studied for their effects on weight management and metabolism. One of particular note is IL-18, which was shown to modulate food intake, metabolism, and body fat levels in rats. 12 Later studies have utilized this role of cytokines to improve weight loss and increase insulin sensitivity in human trials.<\/p>\n<p><a href=\"http:\/\/lifeclinic.com.hk\/zh_cn\/contact-us\/\">Contact us<\/a> at LifeClinic to learn more about cytokine therapy and supporting healthy aging at every age.<\/p>\n\n\t\t<\/div>\n\t<\/div>\n<div class=\"vc_empty_space\"   style=\"height: 32px\"><span class=\"vc_empty_space_inner\"><\/span><\/div><\/div><\/div><\/div><\/div><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h4>\u53c2\u8003\u8d44\u6599:<\/h4>\n<p>1. Rea, M., Gibson, D.S., McGilligan, V. et al. Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines. Immunol. (2019) doi.org\/10.3389\/fimmu.2018.00586<br \/>\n2. Donnelly RP, Young HA, Rosenberg AS. An overview of cytokines and cytokine antagonists as therapeutic agents. Ann N Y Acad Sci. 2009;1182:1\u201013. doi:10.1111\/j.1749-6632.2009.05382.x<br \/>\n3. Kopf, M., Bachmann, M. &amp; Marsland, B. Averting inflammation by targeting the cytokine environment. Nat Rev Drug Discov9, 703\u2013718 (2010). doi.org\/10.1038\/nrd2805<br \/>\nZhang JM, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin.<br \/>\n2007;45(2):27\u201037. doi:10.1097\/AIA.0b013e318034194e<br \/>\n5. Borg, M., Brincat, S., Camilleri, G. et al. The role of cytokines in skin aging.<br \/>\n2013;16(5):514-21. doi: 10.3109\/13697137.2013.802303<br \/>\n6. Ardolino, Michele et al. Cytokine treatment in cancer immunotherapy.<br \/>\nOncotarget 6,23 (2015): 19346-7. doi:10.18632\/oncotarget.5095<br \/>\n7. Astrakhantseva, I.V., Efimov, G.A., Drutskaya, M.S. et al. Modern anti-cytokine therapy of autoimmune diseases. Biochemistry Moscow 79, 1308\u20131321 (2014). https:\/\/doi.org\/10.1134\/S0006297914120049<br \/>\n8. Qingdong Guan, Xiaoling Gao, Junhui Wang, Yu Sun, and Sudhanshu Shekhar. Cytokines in Autoimmune Disease. Mediators of Inflammation (2017). doi.org\/10.1155\/2017\/5089815<br \/>\n9. Donzis EJ, Tronson NC. Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences. Neurobiol Learn Mem. 2014;115:68\u201077. doi:10.1016\/j.nlm.2014.08.008<br \/>\n10. Azodi S, Jacobson S. Cytokine Therapies in Neurological Disease. Neurotherapeutics. 2016;13(3):555\u2010561. doi:10.1007\/s13311-016-0455-1<br \/>\n11. Vanderwall Arden G. and Milligan Erin D. Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management. Frontiers in Immunology. 2019;10:3009. doi:10.3389\/fimmu.2019.03009<br \/>\n12. Zorrilla EP, Sanchez-Alavez M, Sugama S, et al. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc Natl Acad Sci U S A. 2007;104(26):11097\u201011102. doi:10.1073\/pnas.0611523104<br \/>\n13. Weiss EP, Reeds DN, Ezekiel UR, Albert SG, Villareal DT. Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity. Endocrine. 2017;55(1):153\u2010164. doi:10.1007\/s12020-016-1093-4<\/p>\n\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"Cytokines, from the Greek cyto meaning \u201ccell\u201d and kinos meaning \u201cmovement\u201d, are tiny protein molecules secreted by cells that communicate with other cells. Cytokines may be classified as peptides, proteins, exosomes, secretomes or glycoproteins. Sophisticated and profound complexes of cytokines found in our bodies are involved in cellular communications. They are nano-sized molecules working as [...]","protected":false},"author":4,"featured_media":6595,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[202],"tags":[],"class_list":["post-6593","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biohacking"],"acf":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/lifeclinic.com.hk\/wp-content\/uploads\/2021\/06\/Cytokine_release.jpeg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/posts\/6593","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/comments?post=6593"}],"version-history":[{"count":3,"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/posts\/6593\/revisions"}],"predecessor-version":[{"id":8873,"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/posts\/6593\/revisions\/8873"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/media\/6595"}],"wp:attachment":[{"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/media?parent=6593"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/categories?post=6593"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeclinic.com.hk\/zh_cn\/wp-json\/wp\/v2\/tags?post=6593"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}